Inorganic nanoparticles for oral drug delivery: opportunities, barriers, and future perspectives
نویسندگان
چکیده
Oral delivery is the preferred route of drug administration due to patient compliance and convenience. Despite this, nanomedicines have so far primarily been developed for parenteral route. Inorganic nanoparticles hold great promise as theranostics oral delivery. This gaining importance especially local treatment gastrointestinal (GI) diseases. However, successful inorganic challenged by complex physiological conditions in GI tract. We discuss main barriers their impact on nanoparticle biotransformation toxicity. An improved understanding interplay with dynamic environment can facilitate development efficient nanomedicines.
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ژورنال
عنوان ژورنال: Current opinion in chemical engineering
سال: 2022
ISSN: ['2211-3398']
DOI: https://doi.org/10.1016/j.coche.2022.100869